Your Practice Online
Synvisc One Hylan G-F 20 Advanced OSM  
Osteoarthritis Knee Pain For Appointments Call Synvisc One Hylan G-F 20: (281) 664 2238
Text Size Font Decreasing Font Increasing
Frequently Asked Questions

Is Synvisc-One® (hylan G-F 20) right for you? Only your doctor can tell you that. But the following list may answer some of your questions. Simply click on a question to see the answer. Click on it again to close it.

When should I consider Synvisc-One?

If you’ve tried diet, exercise and over-the-counter pain medication, and still have knee pain, talk to your doctor, you may be a candidate for Synvisc-One.

When will I start to feel pain relief?

Everyone responds differently, but in a medical study patients experienced pain relief starting one month after the injection of Synvisc-One.

How is Synvisc-One given?

Synvisc-One is a single injection. It’s a simple, in-office procedure that only takes a few minutes. After the injection, you can resume normal day-to-day activities but you should avoid strenuous activities for about 48 hours.

How will the doctor prepare my knee for treatment?

Your doctor may clean your knee with alcohol and iodine. Then, he or she may apply a local anesthetic to your knee, and withdraw any excess fluid from your joint. The doctor will then inject your knee with Synvisc-One.

Are there side effects?

The side effects most commonly seen in a medical study were knee pain, stiffness and swelling or fluid buildup in or around the knee. Other side effects, such as rash, may also occur. Side effects were generally mild to moderate and did not last long. Synvisc-One does not have the serious side effects associated with many pain pills.

How long will I experience relief?

Although all patients respond differently, osteoarthritis knee pain relief can last up to six months

Should I reduce my activity after being treated with Synvisc-One?

After the injection, you can resume normal day-to-day activities, but you should avoid any strenuous activities for about 48 hours.

Is Synvisc-One covered by insurance?

Synvisc-One treatment is eligible for reimbursement by Medicare and most insurance plans. Check with your insurance plan to determine your exact benefits. Many insurers require that you obtain Synvisc-One through your doctor. If your doctor writes you a prescription for Synvisc-One, some insurance plans, including Medicare, may not cover the cost. Therefore, it is recommended that you check with your insurer prior to receiving a prescription. If you are denied insurance coverage for your Synvisc-One treatment, please contact the SYNVISC ConnectionSM at 1-800-982-8292, M–F, 9am–8pm (ET).

How is Synvisc-One different from SYNVISC®?

Synvisc-One is the same formulation as SYNVISC. The only difference is that Synvisc-One is provided with one injection, compared to the three injections required for SYNVISC. Both treatments can provide up to six months of pain relief.

Can I receive Synvisc-One more than once?

Yes, Synvisc-One can be repeated safely. So if your knee pain returns, talk to your doctor about whether another Synvisc-One treatment is right for you.

Can both my knees be treated with Synvisc-One?

Yes. You can receive treatment in both knees at the same time, or at different times. Ask your doctor what is best for you.

Alain Elbaz, MD. – Orthopaedic Surgeon Meet Dr Alain Elbaz
Alain Elbaz, MD.
Orthopaedic Surgeon
View Profile
Facebook Twitter Linkedin YouTube


Synvisc-One® (hylan G-F 20) and SYNVISC® (hylan G-F 20) are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.


Important Safety Information

Before trying Synvisc-One or SYNVISC, tell your doctor if you are allergic to products from birds—such as feathers, eggs or poultry—or if your leg is swollen or infected. Synvisc-One and SYNVISC are only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One and SYNVISC have not been tested to show pain relief in joints other than the knee. Talk to your doctor before resuming strenuous weight-bearing activities after treatment. Synvisc-One and SYNVISC have not been tested in children, pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. The side effects most commonly seen when Synvisc-One or SYNVISC is injected into the knee were pain, swelling and/or fluid buildup in or around the knee. Cases where the swelling is extensive or painful should be discussed with your doctor. Allergic reactions such as rash and hives have been reported rarely.

View the Complete Prescribing Information for Synvisc-One (PDF)
View the Complete Prescribing Information for SYNVISC (PDF)


© Alain Elbaz MD Orthopaedic Hip Knee & Shoulder Surgeon Cypress Houston Texas